KMID : 1009020190170030364
|
|
Clinical Psychopharmacology and Neuroscience 2019 Volume.17 No. 3 p.364 ~ p.368
|
|
Genes Involved in Neurodevelopment, Neuroplasticity and Major Depression: No Association for CACNA1C, CHRNA7 and MAPK1
|
|
Calabro Marco
Mandelli Laura Crisafulli Concetta Lee Soo-Jung Jun Tae-Youn Wang Sheng-Min Patkar Ashwin A. Masand Prakash S. Han Chang-Su Pae Chi-Un Serretti Alessandro
|
|
Abstract
|
|
|
Objective: Genetics factors are likely to play a role in the risk, clinical presentation and treatment outcome in major depressive disorder (MDD). In this study, we investigated the role of three candidate genes for MDD; calcium voltage- gated channel subunit alpha1 C ( CACNA1C ), cholinergic receptor nicotinic alpha 7 subunit ( CHRNA7 ), and mitogen- activated protein kinase 1 ( MAPK1 ).
Methods: Two-hundred forty-two MDD patients and 326 healthy controls of Korean ancestry served as samples for the analyses. Thirty-nine single nucleotide polymorphisms (SNPs) within CACNA1C , CHRNA7 , and MAPK1 genes were genotyped and subsequently tested for association with MDD (primary analysis) and other clinical features (symptoms¡¯ severity, age of onset, history of suicide attempt, treatment outcome) (secondary analyses). Single SNPs, haplotypes and epistatic analyses were performed.
Results: Single SNPs were not associated with disease risk and clinical features. However, a combination of alleles (haplotype) within MAPK1 was found associated with MDD-status. Secondary analyses detected a possible involvement of CACNA1C haplotype in resistance to antidepressant treatment.
Conclusion: These data suggest a role for MAPK1 and CACNA1C in MDD risk and treatment resistance, respectively. However, since many limitations characterize the analysis, the results must be considered with great caution and verified.
|
|
KEYWORD
|
|
MAPK1, CACNA1C, CHRNA7, Major depressive disorder, Deep phenotyping
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|